The teams conducts research on cancer prevention. Currently, research in cooperation with the Medical University of Lviv (Ukraine) concentrates on the anticancer potential of newly synthesized thiazolidenedione of in-vitro cell culture model. The study is a continuation of cytotoxicity studies of newly synthesized compounds from the group of thiazolidenedionees. The research also concerns analysis of the impact of selected plant extracts on the growth of prostate cancer cells and on the regulation of membrane protein activity impacting the development and survival of cancer cells.
Contact: smika@wsiz.edu.pl
Research financed from the means of the Ministry of Science and Higher Education:
Subject: Cytotoxic and immunomodulatory properties of thiazolidenediones and cannabinoids
Project Manager: Prof. Jan Gmiński, Ph.D.
The aim of the research is to determine the cytotoxicity of newly synthesized compounds from the thiazolidenedione group. Compounds of this group are currently widely used PPARγ agonists, the activation of which causes apoptotic death of cancer cells. In addition, thiazolidenediones are currently used to treat insulin resistance and type 2 diabetes. Implementation period: 2015–2017, and since 2018 as “Anticancer effect of newly synthesized thiazolidenediones in in-vitro cell cultures”. The aim of the planned research is to determine the molecular mechanism of action and anticancer properties of newly synthesized thiazolidenediones (Les-2194, Les-3377 and Les-3640).
Implementation period: 2018–2020
Subject: Effect of VGVAPG peptide on lipid accumulation and inflammatory process in 3T3 cell lines
Project Manager: Prof. Jan Gmiński, Ph.D.
Elastin is the main component of the extracellular matrix in mammalian organisms. Degradation of the elastin-rich extracellular matrix by proteinases derived from the serum and secreted from infiltrating platelets, leukocytes, causes the release of short peptides with the properties of cytokines, i.e. EDPs (elastin-derived peptides). In addition, both type-2 diabetes and cardiometabolic diseases have increased levels of EDPs and anti-elastin antibodies. Therefore, the subject of the proposed research will be to determine the impact mechanism of the peptide resulting from the breakdown of elastin with the conserved sequence Val-Gly-Val-Ala-Pro-Gly (VGVAPG) on metabolism, production of proinflammatory cytokines and lipid accumulation in 3T3 cells.
Implementation period: 2019-2020
